Em. Prof. Dr. Arthur Van Aerschot

contact

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research projects

• Crystallographic facility for target-based drug design [more...]
• Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors [more...]
• Structure-guided design and development of antivirals targeting BK polyomavirus capsid [more...]

recent publications

• Vantieghem, T., Aslam, N.A., Osipov, E.M., Akele, M., Van Belle, S., Beelen, S., Drexler, M., Paulovcakova, T., Lux, V., Fearon, D., Douangamath, A., von Delft, F., Christ, F., Veverka, V., Verwilst, P., Van Aerschot, A., Debyser, Z., Strelkov, S.V. with Strelkov, S.V. (corresp. author) (2024). Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 280, Art.No. ARTN 116960. doi: 10.1016/j.ejmech.2024.116960
• Vantieghem, T., Ahmad Aslam, N., Osipov, E., Akele, T., Van Belle, S., Beelen, S., Drexler, M., Lux, V., Fearon, D., Douangamath, A., von Delft, F., Christ, F., Veverka, V., Verwilst, P., Van Aerschot, A., Debyser, Z., Strelkov, S. (2024). Rational fragment-based approach to targeting the LEDGF PWWP domain in HIV infection and MLL-r leukemia. Presented at the Protein Sciences in Drug Discovery 2024, Cambridge, UK.
• Vantieghem, T., Ahmad Aslam, N., Osipov, E.M., Akele, T., Van Belle, S., Beelen, S., Drexler, M., Lux, V., Fearon, D., Douangamath, A., von Delft, F., Christ, F., Veverka, V., Van Aerschot, A., Debyser, Z., Strelkov, S.V. (2024). Rational fragment-based approach to targeting the LEDGF PWWP domain in HIV infection and MLL-r leukemia. Presented at the Drug Discovery Chemistry 2024, San Diego, USA, 31 Mar 2024-04 Apr 2024.
• Lenders, S., Verwilst, P. (sup.), Strelkov, S. (cosup.), Van Aerschot, A. (cosup.) (2023). Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors.
• Pang, L., Lenders, S., Osipov, E.M., Weeks, S.D., Rozenski, J., Piller, T., Cappoen, D., Strelkov, S.V., Van Aerschot, A. with Van Aerschot, A. (corresp. author) (2022). Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (23), Art.No. ARTN 15095. doi: 10.3390/ijms232315095
• Ahmad Aslam, N., Vantieghem, T., Osipov, E., Van Belle, S., Christ, F., Debyser, Z., Van Aerschot, A., Strelkov, S. (2022). FRAGMENT-BASED DISCOVERY OF SMALL MOLECULE ANTAGONISTS TARGETING THE CHROMATIN READING FUNCTION OF LEDGF/p75. Presented at the EFMC-ISMC International Symposium on Medicinal Chemistry, Nice, France, 04 Sep 2022-08 Sep 2022.
• Pang, L., Zanki, V., Strelkov, S., Van Aerschot, A., Gruic-Sovulj, I., Weeks, S.D. with Van Aerschot, A. (corresp. author), Gruic-Sovulj, I. (corresp. author), Weeks, S.D. (corresp. author) (2022). Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. COMMUNICATIONS BIOLOGY, 5 (1), Art.No. ARTN 883. doi: 10.1038/s42003-022-03825-8
• Ahmad Aslam, N., Vantieghem, T., Osipov, E., Van Belle, S., Christ, F., Debyser, Z., Van Aerschot, A., Strelkov, S. (2022). Fragment-based discovery of small molecule antagonists targeting the chromatin reading function of LEDGF/p75. Presented at the 8th Young researchers symposium of the Spanish Society of Medicinal Chemistry (SEQT), Barcelona, Spain, 22 Jul 2022-22 Jul 2022.
• Ahmad Aslam, N., Vantieghem, T., Osipov, E., Van Belle, S., Christ, F., Debyser, Z., Van Aerschot, A., Strelkov, S. (2022). Fragment-based discovery of small molecule antagonists targeting the chromatin reading function of LEDGF/p75. Presented at the 7th SEQT Summer School - Medicinal Chemistry and Chemical Biology in Drug Discovery: The Pharma Perspective, Barcelona, Spain, 19 Jul 2022-21 Jul 2022.
• Osipov, E., Munawar, A., Beelen, S., Fearon, D., Douangamath, A., Wild, C., Weeks, S., Van Aerschot, A., Von Delft, F., Strelkov, S. (2022). Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors. RSC CHEMICAL BIOLOGY. doi: 10.1039/d2cb00052k

For a complete list of publications, see lirias database or PubMed.