Laboratory for Medicinal Chemistry - recent publications

All our publications can be retrieved through the Rega Institute publications database or through Lirias, the KU Leuven digital repository. Below a list of recently published papers:

• Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids, El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts L, Alanjary M, Zdouc M, de los Santos E, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema M, Weir A, Lescrinier E, Masschelein J, JACS Au; 2026; Vol. 6; iss. 6; pp. 3363 - 3375, doi: 10.1021/jacsau.6c00386
• Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors, Gao L, Kalebic D, Lo C, Gangwal A, Tran D, Rozenski J, Schols D, Froeyen M, Dehaen W, Einav S, De Jonghe S, Frontiers In Chemistry; 2026; Vol. 14, doi: 10.3389/fchem.2026.1777981
• Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors, Zhang X, Sun L, Walsham L, Ma Y, Ding D, Wang M, Zhao F, Zhang J, Wang Z, Xu S, Jiang X, Zhou Y, De Clercq E, Pannecouque C, Chen C, Goldstone D, Liu X, Dick A, Zhan P, MedComm; 2026; Vol. 7; iss. 5, doi: 10.1002/mco2.70746
• Are we there yet with XNA aptamers?, Chaillou S, Thonon S, Reynders S, Lescrinier E, Pinheiro V, Rsc Advances; 2026; Vol. 16; iss. 24; pp. 22227 - 22246, doi: 10.1039/d5ra05395a
• Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice., Koutsoumpou X, Lenders V, Krishnamoorthy A, Vlaeminck I, Rozenski J, De Marco F, Luci C, Goncalves F, Girmatsion H, Ciwinksa M, Nobis M, Scheele C, Soenen S, De Vleeschouwer S, Manshian B, Journal Of Nanobiotechnology; 2026; Vol. 24; iss. 1, doi: 10.1186/s12951-026-04350-0
• Ugi-Tetrazole-Derived α-Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV-2 3CLpro, van der Straat R, Oerlemans R, Cong Y, Boxma J, Bulai R, Río-Bergé C, Koekemoer L, Tzitzikas T, Guan Z, Marples P, Reggiori F, Groves M, Dömling A, Acs Medicinal Chemistry Letters; 2026; Vol. 17; iss. 4, doi: 10.1021/acsmedchemlett.5c00773
• Synthesis, structure-activity relationship study and molecular modeling of triazolo[4,5-d]pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors, Omanakuttan V, Froeyen M, Claes S, Van Bosstraeten B, Boon K, Schols D, Van Meervelt L, Van Loy T, Dehaen W, De Jonghe S, European Journal Of Medicinal Chemistry; 2026; Vol. 306, doi: 10.1016/j.ejmech.2026.118597
• LiraSearch-ultrafast ligand shape and electrostatic matching server, Montalvao R, Bray S, Verissimo-Alves M, Cubero E, Gruning B, Pinheiro V, Bioinformatics Advances; 2026; Vol. 6; iss. 1, doi: 10.1093/bioadv/vbag139
• Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue, Anthonissen S, Van Eynde W, Karim M, Gao L, Tran D, Schols D, Voet A, Einav S, Dehaen W, De Jonghe S, European Journal Of Medicinal Chemistry; 2025; Vol. 299, doi: 10.1016/j.ejmech.2025.118001
• The Spatial Spillover Effects of Green Bonds: A Local and Neighbouring Perspective on Carbon Mitigation, Liang K, Mei L, Jian Y, Zhou X, Gao L, Ecological Chemistry And Engineering S-Chemia I Inzynieria Ekologiczna S; 2025; Vol. 32; iss. 4; pp. 589 - 603, doi: 10.2478/eces-2025-0031
• China maakt als tweede grootste medicijnenproducent ook alsmaar meer innovatieve medicatie, De Morgen; 2025
• Opmars van chinese bedrijven zet belgische farmasector onder druk, Het Laatste Nieuws; 2025
• Structure elucidation and quantification of the active pharmaceutical ingredient in a non-approved drug and in cat serum using QTRAP-MS/MS and ZenoTOF-MS/MS, Tu L, Horak J, Krentz D, Zwicklbauer K, Hartmann K, Lescrinier E, Alberer M, von Both U, Koletzko B, Journal Of Pharmaceutical And Biomedical Analysis; 2025; Vol. 265, doi: 10.1016/j.jpba.2025.116995
• The assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumor immunity, Cinque S, Verheyden Y, Adnane S, Marino A, Hanache S, Vendramin R, Cuomo A, Pozniak J, Cortes Calabuig A, Baldewijns M, Tabruyn S, Bechter O, Baietti M, Groaz E, Bonaldi T, Leucci E, Journal Of Experimental Medicine; 2025; Vol. 223; iss. 1, doi: 10.1084/jem.20251507
• A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy, Zhang Z, D'Hondt S, Van der Kant R, Hermans G, Geukens N, Pinheiro V, Schymkowitz J, Rousseau F, Dewilde M, Nucleic Acids Research; 2025; Vol. 53; iss. 19, doi: 10.1093/nar/gkaf1001
• Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors, Goffin E, Torfs L, Tsingis F, Svestka D, Erven K, Uyttersprot K, Heens C, Wilms S, Rozenski J, Lescrinier E, Pannecouque C, Verwilst P, European Journal Of Medicinal Chemistry; 2025; Vol. 296, doi: 10.1016/j.ejmech.2025.117818