Laboratory for Medicinal Chemistry - recent publications

All our publications can be retrieved through the Rega Institute publications database or through Lirias, the KU Leuven digital repository. Below a list of recently published papers:

• 6-Substituted 7-Deazapurine Ribonucleosides Capable of Non-canonical Base Recognition as Inhibitors of Respiratory RNA Viruses., Groaz E, Zheng Z, Hurst B, Burlein C, Bahnck-Teets C, Devito K, Nie P, Maity S, Choi J, Nguyen H, Li Q, Stevaert A, Froeyen M, Naesens L, Julander J, Adam G, Herdewijn P, J Med Chem; 2026; Vol. 69; iss. 20; pp. 24365 - 24387, doi: 10.1021/acs.jmedchem.6c01962
• Polarity-Driven Scaffold Optimization of Diaryl Ether FabV Inhibitors to Enhance Aqueous Solubility, Bulai R, Parolini M, Cummins K, Purnal S, Lescrinier E, Rozenski J, Masschelein J, Verwilst P, Chemmedchem; 2026; Vol. 21; iss. 19, doi: 10.1002/cmdc.70512
• An automated dual-mode platform for affinity-based screening of natural products using a pressure-driven strategy, Jian J, Wolfs K, Ciacci F, Tian H, Rozenski J, Vankelecom I, Jiang Z, Adams E, Van Schepdael A, Analytica Chimica Acta; 2026; Vol. 1418, doi: 10.1016/j.aca.2026.345875
• Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve, Gao L, Froeyen M, Lo C, Tran D, Van Loy T, Schols D, Rozenski J, Dehaen W, Einav S, De Jonghe S, Bioorganic Chemistry; 2026; Vol. 181, doi: 10.1016/j.bioorg.2026.110337
• Synthesis and Antiviral Evaluation of Sugar-Modified Pseudouridine Analogs, Chen Z, Groaz E, Rozenski J, De Jonghe S, Lescrinier E, European Journal Of Organic Chemistry; 2026; Vol. 29; iss. 37, doi: 10.1002/ejoc.70799
• MODULAR CLICK-CHEMISTRY-BASED ENGINEERING MINIMALLY PERTURBS CRISPR RIBONUCLEOPROTEIN FORMATION FOR GENOME IMAGING APPLICATIONS, Van Tricht C, Thonon S, Wouters D, Sifrim A, Vandereyken K, Bernardes Pinheiro V, Voet T, Lammertyn J, Spasic D, bioRxiv; 2026, doi: 10.64898/2026.09.10.750574
• Bioassay-guided Isolation of Antibacterial Compounds from Ethanolic Extract of Alstonia scholaris (L.) R. Br. Leaves and Developmental Toxicity Evaluation in Zebrafish (Danio rerio) Embryos, Ahmed F, Luyten W, Rozenski J, Paeshuyse J, Current Microbiology; 2026; Vol. 83; iss. 8, doi: 10.1007/s00284-026-05031-9
• Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids, El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts L, Alanjary M, Zdouc M, de los Santos E, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema M, Weir A, Lescrinier E, Masschelein J, JACS Au; 2026; Vol. 6; iss. 6; pp. 3363 - 3375, doi: 10.1021/jacsau.6c00386
• Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors, Gao L, Kalebic D, Lo C, Gangwal A, Tran D, Rozenski J, Schols D, Froeyen M, Dehaen W, Einav S, De Jonghe S, Frontiers In Chemistry; 2026; Vol. 14, doi: 10.3389/fchem.2026.1777981
• Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors, Zhang X, Sun L, Walsham L, Ma Y, Ding D, Wang M, Zhao F, Zhang J, Wang Z, Xu S, Jiang X, Zhou Y, De Clercq E, Pannecouque C, Chen C, Goldstone D, Liu X, Dick A, Zhan P, MedComm; 2026; Vol. 7; iss. 5, doi: 10.1002/mco2.70746
• Are we there yet with XNA aptamers?, Chaillou S, Thonon S, Reynders S, Lescrinier E, Pinheiro V, Rsc Advances; 2026; Vol. 16; iss. 24; pp. 22227 - 22246, doi: 10.1039/d5ra05395a
• Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice., Koutsoumpou X, Lenders V, Krishnamoorthy A, Vlaeminck I, Rozenski J, De Marco F, Luci C, Goncalves F, Girmatsion H, Ciwinksa M, Nobis M, Scheele C, Soenen S, De Vleeschouwer S, Manshian B, Journal Of Nanobiotechnology; 2026; Vol. 24; iss. 1, doi: 10.1186/s12951-026-04350-0
• Ugi-Tetrazole-Derived α-Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV-2 3CLpro, van der Straat R, Oerlemans R, Cong Y, Boxma J, Bulai R, Río-Bergé C, Koekemoer L, Tzitzikas T, Guan Z, Marples P, Reggiori F, Groves M, Dömling A, Acs Medicinal Chemistry Letters; 2026; Vol. 17; iss. 4, doi: 10.1021/acsmedchemlett.5c00773
• LiraSearch-ultrafast ligand shape and electrostatic matching server, Montalvao R, Bray S, Verissimo-Alves M, Cubero E, Gruning B, Pinheiro V, Bioinformatics Advances; 2026; Vol. 6; iss. 1, doi: 10.1093/bioadv/vbag139
• Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue, Anthonissen S, Van Eynde W, Karim M, Gao L, Tran D, Schols D, Voet A, Einav S, Dehaen W, De Jonghe S, European Journal Of Medicinal Chemistry; 2025; Vol. 299, doi: 10.1016/j.ejmech.2025.118001
• The Spatial Spillover Effects of Green Bonds: A Local and Neighbouring Perspective on Carbon Mitigation, Liang K, Mei L, Jian Y, Zhou X, Gao L, Ecological Chemistry And Engineering S-Chemia I Inzynieria Ekologiczna S; 2025; Vol. 32; iss. 4; pp. 589 - 603, doi: 10.2478/eces-2025-0031