Laboratory for Medicinal Chemistry - recent publications

All our publications can be retrieved through the Rega Institute publications database or through Lirias, the KU Leuven digital repository. Below a list of recently published papers:

• Synthesis, structure-activity relationship study and molecular modeling of triazolo[4,5-d]pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors, Omanakuttan V, Froeyen M, Claes S, Van Bosstraeten B, Boon K, Schols D, Van Meervelt L, Van Loy T, Dehaen W, De Jonghe S, European Journal Of Medicinal Chemistry; 2026; Vol. 306, doi: 10.1016/j.ejmech.2026.118597
• Ugi-Tetrazole-Derived α-Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV-2 3CLpro, van der Straat R, Oerlemans R, Cong Y, Boxma J, Bulai R, Río-Bergé C, Koekemoer L, Tzitzikas T, Guan Z, Marples P, Reggiori F, Groves M, Dömling A, Acs Medicinal Chemistry Letters; 2026, doi: 10.1021/acsmedchemlett.5c00773
• Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue, Anthonissen S, Van Eynde W, Karim M, Gao L, Tran D, Schols D, Voet A, Einav S, Dehaen W, De Jonghe S, European Journal Of Medicinal Chemistry; 2025; Vol. 299, doi: 10.1016/j.ejmech.2025.118001
• The Spatial Spillover Effects of Green Bonds: A Local and Neighbouring Perspective on Carbon Mitigation, Liang K, Mei L, Jian Y, Zhou X, Gao L, Ecological Chemistry And Engineering S-Chemia I Inzynieria Ekologiczna S; 2025; Vol. 32; iss. 4; pp. 589 - 603, doi: 10.2478/eces-2025-0031
• China maakt als tweede grootste medicijnenproducent ook alsmaar meer innovatieve medicatie, De Morgen; 2025
• Opmars van chinese bedrijven zet belgische farmasector onder druk, Het Laatste Nieuws; 2025
• Structure elucidation and quantification of the active pharmaceutical ingredient in a non-approved drug and in cat serum using QTRAP-MS/MS and ZenoTOF-MS/MS, Tu L, Horak J, Krentz D, Zwicklbauer K, Hartmann K, Lescrinier E, Alberer M, von Both U, Koletzko B, Journal Of Pharmaceutical And Biomedical Analysis; 2025; Vol. 265, doi: 10.1016/j.jpba.2025.116995
• The assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumor immunity, Cinque S, Verheyden Y, Adnane S, Marino A, Hanache S, Vendramin R, Cuomo A, Pozniak J, Cortes Calabuig A, Baldewijns M, Tabruyn S, Bechter O, Baietti M, Groaz E, Bonaldi T, Leucci E, Journal Of Experimental Medicine; 2025; Vol. 223; iss. 1, doi: 10.1084/jem.20251507
• A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy, Zhang Z, D'Hondt S, Van der Kant R, Hermans G, Geukens N, Pinheiro V, Schymkowitz J, Rousseau F, Dewilde M, Nucleic Acids Research; 2025; Vol. 53; iss. 19, doi: 10.1093/nar/gkaf1001
• Investigating the structure-activity-relationship of diaryl ether-based paFabV inhibitors: A path to novel antibacterials, Bulai R, Van Eynde W, Heylen S, Cremonini M, Van Olmen F, Wicik R, Lescrinier E, Rozenski J, Voet A, Masschelein J, Verwilst P, European Journal Of Medicinal Chemistry; 2025; Vol. 296, doi: 10.1016/j.ejmech.2025.117782
• Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors, Goffin E, Torfs L, Tsingis F, Svestka D, Erven K, Uyttersprot K, Heens C, Wilms S, Rozenski J, Lescrinier E, Pannecouque C, Verwilst P, European Journal Of Medicinal Chemistry; 2025; Vol. 296, doi: 10.1016/j.ejmech.2025.117818
• Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues, Derden M, Reynders S, Rihon J, Li X, Coosemans F, Rozenski J, Herdewijn P, Groaz E, Lescrinier E, Rsc Advances; 2025; Vol. 15; iss. 44; pp. 37099 - 37108, doi: 10.1039/d5ra05934h