Laboratory for Medicinal Chemistry - research projects

Research projects

• MORPHO-ViBe. Developping a new probe harboring vibrational Stark effect spectroscopic sensitivity and targeting the catalytic pocket of the ribosome [more...]
• Continued provision of an affordable medium-parametric cell analysis solution at the KU Leuven Flow Cytometry core facility [more...]
• Continued provision of an affordable medium-parametric cell analysis solution at the KU Leuven Flow Cytometry core facility [more...]
• Exploring the under-exploited bacterial purine biosynthesis pathway towards developing novel antibiotics and biochemical tools. [more...]
• ULtra-high Throughput screening of Microbial metabolites using Echo-MS (ULTiMatE-MS) [more...]
• Development of allosteric intracellular CCR5 signaling modulators to overcome DMPK limitations [more...]
• Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcription [more...]
• Development of FabV inhibitors to combat drug-resistance in pathogenic Gram-negative bacteria [more...]
• Symmetric antibodies for symmetric epitopes: development and validation of the Symbody platform. [more...]
• COLUMBO: Engineered CRISPR toolbox for revolutionizing single-cell genome imaging in embryogenesis and oncology [more...]
• Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signalling [more...]
• Synthetic Biology of mRNA [more...]
• Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
• Unlocking powerful non-model organisms in microbial synthetic biology - POSSIBL. [more...]
• Intravital microscopy platform for infectious and inflammatory diseases [more...]
• An NMR facility tailored for biomedical research [more...]
• Crystallographic facility for target-based drug design [more...]
• HiTMan: a versatile and flexible high-throughput microbe handler for automation of complex experimental procedures and rapid phenotypic characterization [more...]
• Design and developement of diagnostics and drugs for neurodegenerative, immunological and microbial diseases [more...]
• Streamlining the route of phosphonate XNA from chemistry to application [more...]
• Directed evolution of mesophilic DNA polymerases with altered substrate specificity [more...]
• Structure-guided design and development of antivirals targeting BK polyomavirus capsid [more...]
• Directed evolution of mesophilic DNA polymerases with altered substrate specificity [more...]
• Directed evolution as a tool in Synthetic Biology. [more...]

Doctoral projects

• Exploring Novel Synergies Between Antiviral Nucleotides and Small Molecule Immunomodulators for Hepatitis B virus (HBV) Treatment [more...]
• Exploring CCR5 signaling modulators through integrated computational and synthetic methods [more...]
• Exploring the development of PurK inhibitors in pursuit of novel antibacterial strategies [more...]
• Development of alkyl-PMO based antibiotics [more...]
• An exploration of pincer-type intracellular CCR5 antagonists [more...]
• Harnessing the Power of DNA-Encoded Libraries to Identify and Expand Novel Hits to Develop Urgently Needed P. aeruginosa Antibiotics [more...]
• Design of targeted degraders of LEDGF/p75 with applications as anticancer agents [more...]
• Developing XNA aptamer selection tools for the advancement of aptamer diagnostic and therapeutic applications [more...]
• Computational design of a symmetric scaffold protein for small molecule biosensing [more...]
• Development of broad spectrum antibiotics with a new mode of action through establishing new tools for optimal sequence selection in vitro and in silico design of antisense oligonucleotides. [more...]
• Spatial control of enzymatic DNA assembly using ion charging layers [more...]
• Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2 [more...]
• Development of Small-Molecule Inhibitors of FabV Effective in Gram-negative Bacteria [more...]
• Developing cross-species genetic tools and a standardized genetic circuit for non-model microorganism engineering [more...]
• Directed evolution of bioactive compounds: Azol(in)e-containing post-translationally modified peptides [more...]
• Redesigning Biology: Changing the substrate requirements of DNA polymerases by directed evolution [more...]
• Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backbone [more...]
• Structure-based design of HBV polymerase inhibitors [more...]
• Molecular modeling tools to improve and expand computational research on synthetic nucleic acids [more...]
• Engineering yeast chassis strains for highly efficient limonene production [more...]
• Design and synthesis of next-generation C-C chemokine receptor type 5 antagonists. [more...]
• Development and optimization of novel XNA aptamers [more...]
• Synthesis of nucleoside analogues as antiviral and antibacterial agents [more...]
• Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors [more...]
• Development and SAR exploration of novel doravirine- and catechol-derived hybrid NNRTIs [more...]
• Directed evolution of bioactive compounds: Azol(in)e-containing post-translationally modified peptides [more...]
• Exploring the Sequence and Functional Landscapes of Natural and Engineered Polymerases [more...]
• Xylo-type phosphonate nucleic acids: synthesis and structure analysis [more...]
• Synthesis and structure determination of phosphonate oligonucleotides [more...]
• IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES [more...]
• Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]
• Development of XNA ligases as tools for synthetic biology [more...]