Prof. Dr. Eveline Lescrinier

contact

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research projects

• MORPHO-ViBe. Developping a new probe harboring vibrational Stark effect spectroscopic sensitivity and targeting the catalytic pocket of the ribosome [more...]
• Exploring Novel Synergies Between Antiviral Nucleotides and Small Molecule Immunomodulators for Hepatitis B virus (HBV) Treatment [more...]
• Development of alkyl-PMO based antibiotics [more...]
• Developing XNA aptamer selection tools for the advancement of aptamer diagnostic and therapeutic applications [more...]
• Development of broad spectrum antibiotics with a new mode of action through establishing new tools for optimal sequence selection in vitro and in silico design of antisense oligonucleotides. [more...]
• Stereo-controlled synthesis of artificial genetic systems with modified sugar phosphate backbone [more...]
• Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
• Molecular modeling tools to improve and expand computational research on synthetic nucleic acids [more...]
• Development and optimization of novel XNA aptamers [more...]
• An NMR facility tailored for biomedical research [more...]

recent publications

• Tu, L., Horak, J., Krentz, D., Zwicklbauer, K., Hartmann, K., Lescrinier, E., Alberer, M., von Both, U., Koletzko, B. with Horak, J. (corresp. author), Koletzko, B. (corresp. author) (2025). Structure elucidation and quantification of the active pharmaceutical ingredient in a non-approved drug and in cat serum using QTRAP-MS/MS and ZenoTOF-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 265, Art.No. ARTN 116995. doi: 10.1016/j.jpba.2025.116995
• Bulai, R-G., Van Eynde, W., Heylen, S., Cremonini, M., Van Olmen, F., Wicik, R., Lescrinier, E., Rozenski, J., Voet, A., Masschelein, J., Verwilst, P. with Masschelein, J. (corresp. author), Verwilst, P. (corresp. author) (2025). Investigating the structure-activity-relationship of diaryl ether-based paFabV inhibitors: A path to novel antibacterials. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117782. doi: 10.1016/j.ejmech.2025.117782
• Goffin, E., Torfs, L., Tsingis, F., Svestka, D., Erven, K., Uyttersprot, K., Heens, C., Wilms, S., Rozenski, J., Lescrinier, E., Pannecouque, C., Verwilst, P. with Verwilst, P. (corresp. author) (2025). Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117818. doi: 10.1016/j.ejmech.2025.117818
• Struyf, T., Lindberg, C.L., Fjellheim, S., Lescrinier, E., Van den Ende, W. (2025). Discovery of two novel galacto-oligosaccharides from Eranthis Hyemalis (Ranunculaceae), a winter flowering species. Presented at the International Plant Cold Hardiness Seminar, Clermont-Ferrand, France, 26 Jun 2025-30 Jun 2025.
• Billen, M., Reynders, S., Claes, S., Kleinboelting, S., Rozenski, J., Bulai, R-G., Rocca, E., Homer, N.Z M., Webster, S.P., Kaminski, T.P., Lescrinier, E., Schols, D., Verwilst, P. with Verwilst, P. (corresp. author) (2025). Discovery and exploration of disubstituted [1,2,5]oxadiazolo-[3,4-b]pyrazines as novel C-C chemokine receptor type 5 signaling inhibitors targeting the intracellular allosteric binding pocket. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 291, Art.No. ARTN 117600. doi: 10.1016/j.ejmech.2025.117600
• Li, X., Lescrinier, E. (sup.), Groaz, E. (cosup.), Herdewyn, P. (cosup.) (2025). Synthesis and structure determination of phosphonate oligonucleotides.
• Xu, Y., Reynders, S., Coosemans, F., Herdewyn, P., Groaz, E., Lescrinier, E. (2025). Synthesis of Xylo-nucleoside H-Phosphinates and Insights into Their Conformational Preferences Within a Chimeric Duplex. European Journal Of Organic Chemistry, Art.No. ejoc.202500141. doi: 10.1002/ejoc.202500141
• Rihon, J., Lescrinier, E. (sup.), Bernardes Pinheiro, V. (cosup.), Froeyen, M. (cosup.) (2025). Molecular modeling tools to improve and expand computational research on synthetic nucleic acids.
• Rihon, J., Reynders, S., Bernades Pinheiro, V., Lescrinier, E. (2025). The pucke.rs toolkit to facilitate sampling the conformational space of biomolecular monomers. Journal Of Cheminformatics.
• Rocha-Pereira, J., Van Dycke, J., Dos Santos Ferreira, N., Korompai, A., Roux, E., Wevers, N., Goor, S., Molineaux, L., Hubart, A., Dallmeier, K., Hanne, M., Simon, C., Trappeniers, K., Delang, L., Van Dun, C., Lyoo, E., Şen, F., Van Langendonck, M., Meert, R., Minner, K., Verwimp, S., Marques, P.E., Slowikowski, E., Truyen, A., Busselot, W., Mattos, M., Schuermans, S., Sadler, R., Nielsen, V., Degryse, J., Lescrinier, E., Bernardes Pinheiro, V., Verwilst, P., Froeyen, M., Baudemprez, L., Reynders, S., Daelemans, D., Jacquemyn, M., Kwanten, B., Deconinck, T., Aerts, Y., Permentier, B., Van Hauwenhuyse, J., Timmermans, J., Lannoo, R., Libaers, E., Janssens, K., Bral, L., Vanstreels, E., Baggen, J., Dierckx, T., Smolders, Y., Punjwani, J. (2025). Everyone must take action against transmissible diseases - 600 years KU Leuven.

For a complete list of publications, see lirias database or PubMed.