Prof. Dr. Jef Rozenski

contact

• see whoiswho
• Erasmus(+) students welcome, send me an email.

research projects

• An NMR facility tailored for biomedical research [more...]
• Streamlining the route of phosphonate XNA from chemistry to application [more...]
• Directed evolution of bioactive compounds: Azol(in)e-containing post-translationally modified peptides [more...]
• Development of XNA ligases as tools for synthetic biology [more...]

recent publications

• Jian, J., Wolfs, K., Ciacci, F., Tian, H., Rozenski, J., Vankelecom, I.F J., Jiang, Z., Adams, E., Van Schepdael, A. (corresp. author) (2026). An automated dual-mode platform for affinity-based screening of natural products using a pressure-driven strategy. ANALYTICA CHIMICA ACTA, 1418, Art.No. ARTN 345875. doi: 10.1016/j.aca.2026.345875
• Gao, L-J., Froeyen, M., Lo, C-W., Tran, D.H N., Van Loy, T., Schols, D., Rozenski, J., Dehaen, W., Einav, S., De Jonghe, S. (corresp. author) (2026). Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve. BIOORGANIC CHEMISTRY, 181, Art.No. ARTN 110337. doi: 10.1016/j.bioorg.2026.110337
• Ahmed, F. (corresp. author), Luyten, W., Rozenski, J., Paeshuyse, J. (2026). Bioassay-guided Isolation of Antibacterial Compounds from Ethanolic Extract of Alstonia scholaris (L.) R. Br. Leaves and Developmental Toxicity Evaluation in Zebrafish (Danio rerio) Embryos. CURRENT MICROBIOLOGY, 83 (8), Art.No. ARTN 450. doi: 10.1007/s00284-026-05031-9
• Gao, L-J., Kalebic, D., Lo, C.W., Gangwal, A., Tran, D.H N., Rozenski, J., Schols, D., Froeyen, M., Dehaen, W., Einav, S., De Jonghe, S. (corresp. author) (2026). Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors. FRONTIERS IN CHEMISTRY, 14, Art.No. ARTN 1777981. doi: 10.3389/fchem.2026.1777981
• Koutsoumpou, X., Lenders, V., Krishnamoorthy, A.L., Vlaeminck, I., Rozenski, J., De Marco, F., Luci, C.R., Goncalves, F.R., Girmatsion, H., Ciwinksa, M., Nobis, M., Scheele, C.L G J., Soenen, S.J., De Vleeschouwer, S., Manshian, B.B. (2026). Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice. Journal Of Nanobiotechnology, 24 (1), Art.No. 540. doi: 10.1186/s12951-026-04350-0
• Kestemont, D., Rozenski, J. (sup.), Bernardes Pinheiro, V. (cosup.), Renders, M. (cosup.) (2025). Development of XNA ligases as tools for synthetic biology.
• Bulai, R-G., Van Eynde, W., Heylen, S., Cremonini, M., Van Olmen, F., Wicik, R., Lescrinier, E., Rozenski, J., Voet, A., Masschelein, J. (corresp. author), Verwilst, P. (corresp. author) (2025). Investigating the structure-activity-relationship of diaryl ether-based paFabV inhibitors: A path to novel antibacterials. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117782. doi: 10.1016/j.ejmech.2025.117782
• Goffin, E., Torfs, L., Tsingis, F., Svestka, D., Erven, K., Uyttersprot, K., Heens, C., Wilms, S., Rozenski, J., Lescrinier, E., Pannecouque, C., Verwilst, P. (corresp. author) (2025). Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117818. doi: 10.1016/j.ejmech.2025.117818
• Derden, M., Reynders, S., Rihon, J., Li, X., Coosemans, F., Rozenski, J., Herdewijn, P., Groaz, E. (corresp. author), Lescrinier, E. (corresp. author) (2025). Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. RSC ADVANCES, 15 (44), 37099-37108. doi: 10.1039/d5ra05934h
• Kalebic, D., Gao, L-J., Martinez-Gualda, B., Karim, M., Saul, S., Tran, D.H N., Rozenski, J., Persoons, L., Schols, D., Dehaen, W., Einav, S., De Jonghe, S. (corresp. author) (2025). Structure-Activity Relationship Study of 3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines as Dual Inhibitors of the Lipid Kinases PIKfyve and PIP4K2C. PHARMACEUTICALS, 18 (9), Art.No. ARTN 1341. doi: 10.3390/ph18091341

For a complete list of publications, see lirias database or PubMed.

links

• Our expertise is available at the Bioanalytical Mass Spectrometry Facility where we offer mass spectrometry services. See website for details.
• the Mass Spectrometry Toolbox
• Belgian Society for Mass Spectrometry
• RNA Modification Database
• SSU Modification Database