Prof. Dr. Mathy Froeyen

contact

• see whoiswho

research projects

• Molecular modeling tools to improve and expand computational research on synthetic nucleic acids [more...]
• An NMR facility tailored for biomedical research [more...]
• Streamlining the route of phosphonate XNA from chemistry to application [more...]
• Exploring the Sequence and Functional Landscapes of Natural and Engineered Polymerases [more...]
• Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]

recent publications

• Rihon, J., Lescrinier, E. (sup.), Bernardes Pinheiro, V. (cosup.), Froeyen, M. (cosup.) (2025). Molecular modeling tools to improve and expand computational research on synthetic nucleic acids.
• Sucman, N.S., Bilan, D.Y., Cojocari, S., Pogrebnoi, V.S., Stingaci, E.P., Khripach, V.A., Zhabinskii, V.N., Tsybruk, T., Grabovec, I.P., Panibrat, O., Persoons, L., Schols, D., Froeyen, M., Shova, S., De Jonghe, S., Macaev, F.Z. with Macaev, F.Z. (corresp. author) (2024). Steroidal 21-imidazolium salt derivatives: Synthesis and anticancer activity. STEROIDS, 210, Art.No. ARTN 109475. doi: 10.1016/j.steroids.2024.109475
• Ivanova, Y., Spittaels, S., Gao, L-J., Schols, D., Van Meervelt, L., Froeyen, M., Dehaen, W., De Jonghe, S. with De Jonghe, S. (corresp. author) (2024). Synthesis and evaluation of isothiazolo[4,5-b]pyridines as cyclin G-associated kinase (GAK) inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY, 22 (36), 7373-7389. doi: 10.1039/d4ob00908h
• Handal, P., Bernardes Pinheiro, V. (sup.), Gkouridis, G. (cosup.), Froeyen, M. (cosup.) (2024). Exploring the sequence and functional landscapes of natural and engineered polymerases through directed evolution.
• Rihon, J., Mattelaer, C-A., Wander Montalvao, R., Froeyen, M., Bernardes Pinheiro, V., Lescrinier, E. (2024). Modeling synthetic nucleic acids using pure in silico parameters in synergy with the Ducque model builder. Presented at the EFMC-ISMC International symposium on medicinal chemistry, Rome, Italy, 01 Sep 2024-05 Sep 2024.
• Groaz, E., Modranka, J., Ploschik, D., Jabgunde, A., Froeyen, M., Jang, M-Y., Wagenknecht, H-A., Herdewijn, P. with Herdewijn, P. (corresp. author) (2024). Impact of sulfur substitution on biotin binding affinity to streptavidin. BIOORGANIC CHEMISTRY, 150, Art.No. ARTN 107600. doi: 10.1016/j.bioorg.2024.107600
• Iman, K., Mirza, M.U., Sadia, F., Froeyen, M., Trant, J.F., Chaudhary, S.U. with Mirza, M.U. (corresp. author), Chaudhary, S.U. (corresp. author) (2024). Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine Protease. VIRUSES-BASEL, 16 (8), Art.No. ARTN 1250. doi: 10.3390/v16081250
• Rihon, J., Mattelaer, C-A., Montalvao, R.W., Froeyen, M., Pinheiro, V.B., Lescrinier, E. with Lescrinier, E. (corresp. author) (2024). Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline. NUCLEIC ACIDS RESEARCH, 52 (6), 2836-2847. doi: 10.1093/nar/gkae135
• Grisez, T., PANIKKASSERY RAVI, N., Froeyen, M., Schols, D., Van Meervelt, L., De Jonghe, S., Dehaen, W. with Dehaen, W. (corresp. author) (2024). Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase. Molecules, 29 (5), Art.No. 954. doi: 10.3390/molecules29050954
• Rihon, J., Mattelaer, C-A., Froeyen, M., Pinheiro, V., Lescrinier, E. (contr.) (2024). Ducque : the (X)NA model builder. 1. doi: 10.1093/nar/gkae135

For a complete list of publications, see lirias database or PubMed.