Em. Prof. Dr. Piet Herdewyn

contact

• see whoiswho

research projects

• Development of nucleoside analogues with broad-spectrum activity against RNA virus infections [more...]
• Structure-based design of HBV polymerase inhibitors [more...]
• Synthetic Biology of mRNA [more...]
• Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
• Defining, analyzing, and engineering functional nucleic acid systems [more...]
• Xylo-type phosphonate nucleic acids: synthesis and structure analysis [more...]
• Synthesis and structure determination of phosphonate oligonucleotides [more...]
• IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES [more...]
• Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]

recent publications

• Groaz, E., Zheng, Z., Hurst, B.L., Burlein, C., Bahnck-Teets, C., Devito, K., Nie, P., Maity, S., Choi, J-A., Nguyen, H.T T., Li, Q., Stevaert, A., Froeyen, M., Naesens, L., Julander, J., Adam, G.C., Herdewijn, P. (2026). 6-Substituted 7-Deazapurine Ribonucleosides Capable of Non-canonical Base Recognition as Inhibitors of Respiratory RNA Viruses. J Med Chem, 69 (20), 24365-24387. doi: 10.1021/acs.jmedchem.6c01962
• Wang, S., Yang, J., Yang, X., Huang, H., Zou, H., Zhang, Y., Zhang, X., Luo, C., Zhao, B. (corresp. author), Liu, F-W. (corresp. author), Herdewijn, P. (corresp. author) (2026). Synthesis and antitumoral evaluation of 3′,4′-unsaturated nucleoside analogues bearing a chlorinated remdesivir-like base. BIOORGANIC CHEMISTRY, 181, Art.No. ARTN 110389. doi: 10.1016/j.bioorg.2026.110389
• Zhang, T., Wang, S., Xu, J., Zhang, Y., Zou, H., Liu, F. (corresp. author), Qin, S. (corresp. author), Herdewijn, P. (corresp. author) (2026). Single-residue engineering of Klenow fragment enables broad acceptance of chemically modified nucleotides. NUCLEIC ACIDS RESEARCH, 54 (13), Art.No. ARTN gkag697. doi: 10.1093/nar/gkag697
• Zhang, Y., Zhu, H-Y., Ma, C-C., Wang, N., Li, Y., Lu, G-L., Dai, X-J., Wang, B., Mamun, M., Li, Y., Zhao, X-Y., Pang, J-R., Guo, N-J., Qi, F-Y., Sun, J-G., Liu, H-M., Liu, F-W., Herdewijn, P. (corresp. author), Zhao, L-F. (corresp. author), Zheng, Y-C. (corresp. author) (2026). Multiple gastric cancer tissue proteomic identification predicts CLU as a biomarker for anti-PD-1 immunotherapy. JOURNAL OF PHARMACEUTICAL ANALYSIS, 16 (7), Art.No. ARTN 101615. doi: 10.1016/j.jpha.2026.101615
• Chaillou, S., Bernardes Pinheiro, V. (sup.), Herdewyn, P. (cosup.), Lescrinier, E. (cosup.) (2026). Defining, analyzing, and engineering functional nucleic acid systems.
• Derden, M., Reynders, S., Rihon, J., Li, X., Coosemans, F., Rozenski, J., Herdewijn, P., Groaz, E. (corresp. author), Lescrinier, E. (corresp. author) (2025). Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. RSC ADVANCES, 15 (44), 37099-37108. doi: 10.1039/d5ra05934h
• Chaput, J.C. (corresp. author), Egli, M. (corresp. author), Herdewijn, P. (corresp. author) (2025). The XNA alphabet. NUCLEIC ACIDS RESEARCH, 53 (13), Art.No. ARTN gkaf635. doi: 10.1093/nar/gkaf635
• Li, X., Lescrinier, E. (sup.), Groaz, E. (cosup.), Herdewyn, P. (cosup.) (2025). Synthesis and structure determination of phosphonate oligonucleotides.
• Al Hamwi, G., Alnouri, M.W., Verdonck, S., Leonczak, P., Chaki, S., Frischbutter, S., Kolkhir, P., Matthey, M., Kopp, C., Bednarski, M., Riedel, Y.K., Marx, D., Clemens, S., Namasivayam, V., Gattner, S., Thimm, D., Sylvester, K., Wolf, K., Kremer, A.E., De Jonghe, S., Wenzel, D., Kotanska, M., Ali, H., Herdewijn, P., Mueller, C.E. (corresp. author) (2025). Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 10 (1), Art.No. ARTN 128. doi: 10.1038/s41392-025-02209-8
• Gutfreund, C., Betz, K., Abramov, M., Coosemans, F., Holliger, P., Herdewijn, P., Marx, A. (corresp. author) (2024). Structural insights into a DNA polymerase reading the xeno nucleic acid HNA. NUCLEIC ACIDS RESEARCH, 53 (1). doi: 10.1093/nar/gkae1156

For a complete list of publications, see lirias database or PubMed.

links

• IS3NA