Em. Prof. Dr. Piet Herdewyn

contact

• see whoiswho

research projects

• Development of nucleoside analogues with broad-spectrum activity against RNA virus infections [more...]
• Structure-based design of HBV polymerase inhibitors [more...]
• Synthetic Biology of mRNA [more...]
• Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
• Defining, analyzing, and engineering functional nucleic acid systems [more...]
• Synthesis and structure determination of phosphonate oligonucleotides [more...]
• Xylo-type phosphonate nucleic acids: synthesis and structure analysis [more...]
• IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES [more...]
• Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]

recent publications

• Chaillou, S., Bernardes Pinheiro, V. (sup.), Herdewyn, P. (cosup.), Lescrinier, E. (cosup.) (2026). Defining, analyzing, and engineering functional nucleic acid systems.
• Derden, M., Reynders, S., Rihon, J., Li, X., Coosemans, F., Rozenski, J., Herdewijn, P., Groaz, E. (corresp. author), Lescrinier, E. (corresp. author) (2025). Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. RSC ADVANCES, 15 (44), 37099-37108. doi: 10.1039/d5ra05934h
• Chaput, J.C. (corresp. author), Egli, M. (corresp. author), Herdewijn, P. (corresp. author) (2025). The XNA alphabet. NUCLEIC ACIDS RESEARCH, 53 (13), Art.No. ARTN gkaf635. doi: 10.1093/nar/gkaf635
• Li, X., Lescrinier, E. (sup.), Groaz, E. (cosup.), Herdewyn, P. (cosup.) (2025). Synthesis and structure determination of phosphonate oligonucleotides.
• Al Hamwi, G., Alnouri, M.W., Verdonck, S., Leonczak, P., Chaki, S., Frischbutter, S., Kolkhir, P., Matthey, M., Kopp, C., Bednarski, M., Riedel, Y.K., Marx, D., Clemens, S., Namasivayam, V., Gattner, S., Thimm, D., Sylvester, K., Wolf, K., Kremer, A.E., De Jonghe, S., Wenzel, D., Kotanska, M., Ali, H., Herdewijn, P., Mueller, C.E. (corresp. author) (2025). Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 10 (1), Art.No. ARTN 128. doi: 10.1038/s41392-025-02209-8
• Gutfreund, C., Betz, K., Abramov, M., Coosemans, F., Holliger, P., Herdewijn, P., Marx, A. (corresp. author) (2024). Structural insights into a DNA polymerase reading the xeno nucleic acid HNA. NUCLEIC ACIDS RESEARCH, 53 (1). doi: 10.1093/nar/gkae1156
• De, S., De Jonghe, S., Herdewijn, P. (2024). Synthesis of a 3′-Fluoro-3′-deoxytetrose Adenine Phosphonate (vol 82, pg 9464, 2017). JOURNAL OF ORGANIC CHEMISTRY. doi: 10.1021/acs.joc.4c02215
• Herman, J., Vanstreels, E., Bardiot, D., Prota, A.E., Gaillard, N., Gao, L-J., Vercruysse, T., Persoons, L., Daems, T., Waer, M., Herdewijn, P., Louat, T., Steinmetz, M.O., De Jonghe, S., Sprangers, B., Daelemans, D. (corresp. author) (2024). 3-nitropyridine analogues as novel microtubule-targeting agents. PLOS ONE, 19 (11), Art.No. ARTN e0307153. doi: 10.1371/journal.pone.0307153
• Derden, M., Groaz, E., Herdewyn, P., Holliger, P., Lescrinier, E. (2024). STEREOCONTROLLED SYNTHESIS OF alfa-P-SUBSTITUTED MORPHOLINO NUCLEOSIDE TRIPHOSPHATES. Presented at the EFMC-ISMC International Symposium on Medicinal Chemistry, Rome, Italy, 01 Sep 2024-05 Sep 2024.
• Rodriguez-Robles, E., Mueller, D., Kunzl, T., Nemat, S.J., Edelmann, M.P., Srivastava, P., Louis, D., Groaz, E., Tiefenbacher, K., Roberts, T.M., Herdewijn, P., Marliere, P. (corresp. author), Panke, S. (corresp. author) (2024). Rational design of a bacterial import system for new-to-nature molecules. METABOLIC ENGINEERING, 85, 26-34. doi: 10.1016/j.ymben.2024.05.005

For a complete list of publications, see lirias database or PubMed.

links

• IS3NA