Em. Prof. Dr. Piet Herdewyn

contact

• see whoiswho

research projects

• Development of nucleoside analogues with broad-spectrum activity against RNA virus infections [more...]
• Structure-based design of HBV polymerase inhibitors [more...]
• Synthetic Biology of mRNA [more...]
• Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
• Development and optimization of novel XNA aptamers [more...]
• Synthesis and structure determination of phosphonate oligonucleotides [more...]
• Xylo-type phosphonate nucleic acids: synthesis and structure analysis [more...]
• IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES [more...]
• Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]

recent publications

• Derden, M., Reynders, S., Rihon, J., Li, X., Coosemans, F., Rozenski, J., Herdewijn, P., Groaz, E., Lescrinier, E. with Groaz, E. (corresp. author), Lescrinier, E. (corresp. author) (2025). Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. RSC ADVANCES, 15 (44), 37099-37108. doi: 10.1039/d5ra05934h
• Yan, K., Wang, S., Yang, Z., Liu, S., Gu, D., Han, J., Chen, H., Miao, Y., Liu, H., Liu, H., Herdewijn, P., Ke, Y. with Herdewijn, P. (corresp. author), Ke, Y. (corresp. author) (2025). Design, synthesis, and applications of TCR1: A bifunctional aggregation-induced emission fluorescent probe for simultaneous detection of glutathione and viscosity. DYES AND PIGMENTS, 241, Art.No. ARTN 112857. doi: 10.1016/j.dyepig.2025.112857
• Chaput, J.C., Egli, M., Herdewijn, P. with Chaput, J.C. (corresp. author), Egli, M. (corresp. author), Herdewijn, P. (corresp. author) (2025). The XNA alphabet. NUCLEIC ACIDS RESEARCH, 53 (13), Art.No. ARTN gkaf635. doi: 10.1093/nar/gkaf635
• Xu, Y., Reynders, S., Coosemans, F., Herdewijn, P., Groaz, E., Lescrinier, E. with Groaz, E. (corresp. author), Lescrinier, E. (corresp. author) (2025). Synthesis of Xylo-nucleoside H-Phosphinates and Insights into Their Conformational Preferences Within a Chimeric Duplex. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 28 (18). doi: 10.1002/ejoc.202500141
• Li, X., Lescrinier, E. (sup.), Groaz, E. (cosup.), Herdewyn, P. (cosup.) (2025). Synthesis and structure determination of phosphonate oligonucleotides.
• Lu, J., Liu, Z., Li, Z., Su, J., Zhen, H., Qu, Y., Herdewijn, P., Liu, H., Liu, Y., Wang, Z. with Liu, Y. (corresp. author), Wang, Z. (corresp. author) (2025). A review-plant medicine and its extraction components inhibit influenza virus. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 120, Art.No. ARTN 130151. doi: 10.1016/j.bmcl.2025.130151
• Al Hamwi, G., Alnouri, M.W., Verdonck, S., Leonczak, P., Chaki, S., Frischbutter, S., Kolkhir, P., Matthey, M., Kopp, C., Bednarski, M., Riedel, Y.K., Marx, D., Clemens, S., Namasivayam, V., Gattner, S., Thimm, D., Sylvester, K., Wolf, K., Kremer, A.E., De Jonghe, S., Wenzel, D., Kotanska, M., Ali, H., Herdewijn, P., Mueller, C.E. with Mueller, C.E. (corresp. author) (2025). Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 10 (1), Art.No. ARTN 128. doi: 10.1038/s41392-025-02209-8
• Zhang, Z., Wang, N., Lu, J., Qu, Y., Song, Y., Yang, X., Wei, Z., Zhang, Q., Herdewijn, P., Chang, J., Wang, X-N., Wang, Z. with Chang, J. (corresp. author), Wang, X-N. (corresp. author), Wang, Z. (corresp. author) (2025). Synthesis and pharmacodynamic evaluation of 2-aminoindole derivatives against influenza A virus in vitro/vivo. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 281, Art.No. ARTN 117044. doi: 10.1016/j.ejmech.2024.117044
• Gutfreund, C., Betz, K., Abramov, M., Coosemans, F., Holliger, P., Herdewijn, P., Marx, A. with Marx, A. (corresp. author) (2024). Structural insights into a DNA polymerase reading the xeno nucleic acid HNA. NUCLEIC ACIDS RESEARCH, 53 (1). doi: 10.1093/nar/gkae1156
• De, S., De Jonghe, S., Herdewijn, P. (2024). Synthesis of a 3′-Fluoro-3′-deoxytetrose Adenine Phosphonate (vol 82, pg 9464, 2017). JOURNAL OF ORGANIC CHEMISTRY. doi: 10.1021/acs.joc.4c02215

For a complete list of publications, see lirias database or PubMed.

links

• IS3NA