Em. Prof. Dr. Piet Herdewyn
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research projects
- Structure-based design of HBV polymerase inhibitors [more...]
- Synthetic Biology of mRNA [more...]
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. [more...]
- Development and optimization of novel XNA aptamers [more...]
- Xylo-type phosphonate nucleic acids: synthesis and structure analysis [more...]
- Synthesis and structure determination of phosphonate oligonucleotides [more...]
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES [more...]
- Branched acyclic nucleoside phosphonates as prominent source of hepatitis B virus (HBV) inhibitors [more...]
recent publications
- Chaput, J.C., Egli, M., Herdewijn, P. with Chaput, J.C. (corresp. author), Egli, M. (corresp. author), Herdewijn, P. (corresp. author) (2025). The XNA alphabet. NUCLEIC ACIDS RESEARCH, 53 (13), Art.No. ARTN gkaf635. doi: 10.1093/nar/gkaf635
- Li, X., Lescrinier, E. (sup.), Groaz, E. (cosup.), Herdewyn, P. (cosup.) (2025). Synthesis and structure determination of phosphonate oligonucleotides.
- Lu, J., Liu, Z., Li, Z., Su, J., Zhen, H., Qu, Y., Herdewijn, P., Liu, H., Liu, Y., Wang, Z. with Liu, Y. (corresp. author), Wang, Z. (corresp. author) (2025). A review-plant medicine and its extraction components inhibit influenza virus. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 120, Art.No. ARTN 130151. doi: 10.1016/j.bmcl.2025.130151
- Zhang, Z., Wang, N., Lu, J., Qu, Y., Song, Y., Yang, X., Wei, Z., Zhang, Q., Herdewijn, P., Chang, J., Wang, X-N., Wang, Z. with Chang, J. (corresp. author), Wang, X-N. (corresp. author), Wang, Z. (corresp. author) (2025). Synthesis and pharmacodynamic evaluation of 2-aminoindole derivatives against influenza A virus in vitro/vivo. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 281, Art.No. ARTN 117044. doi: 10.1016/j.ejmech.2024.117044
- Gutfreund, C., Betz, K., Abramov, M., Coosemans, F., Holliger, P., Herdewijn, P., Marx, A. with Marx, A. (corresp. author) (2024). Structural insights into a DNA polymerase reading the xeno nucleic acid HNA. NUCLEIC ACIDS RESEARCH, 53 (1). doi: 10.1093/nar/gkae1156
- De, S., De Jonghe, S., Herdewijn, P. (2024). Synthesis of a 3′-Fluoro-3′-deoxytetrose Adenine Phosphonate (vol 82, pg 9464, 2017). JOURNAL OF ORGANIC CHEMISTRY. doi: 10.1021/acs.joc.4c02215
- Rodriguez-Robles, E., Mueller, D., Kunzl, T., Nemat, S.J., Edelmann, M.P., Srivastava, P., Louis, D., Groaz, E., Tiefenbacher, K., Roberts, T.M., Herdewijn, P., Marliere, P., Panke, S. with Marliere, P. (corresp. author), Panke, S. (corresp. author) (2024). Rational design of a bacterial import system for new-to-nature molecules. METABOLIC ENGINEERING, 85, 26-34. doi: 10.1016/j.ymben.2024.05.005
- Groaz, E., Modranka, J., Ploschik, D., Jabgunde, A., Froeyen, M., Jang, M-Y., Wagenknecht, H-A., Herdewijn, P. with Herdewijn, P. (corresp. author) (2024). Impact of sulfur substitution on biotin binding affinity to streptavidin. BIOORGANIC CHEMISTRY, 150, Art.No. ARTN 107600. doi: 10.1016/j.bioorg.2024.107600
- Li, X., Groaz, E., Herdewijn, P., Lescrinier, E. with Lescrinier, E. (corresp. author) (2024). Impact of Single Acyclic Phosphonate Nucleotide (ZNA) Modifications on DNA Duplex Stability. CHEMISTRY-A EUROPEAN JOURNAL, 30 (37). doi: 10.1002/chem.202401254
- Xu, Y., Lescrinier, E. (sup.), Herdewyn, P. (cosup.), Groaz, E. (cosup.) (2024). Xylo-type phosphonate nucleic acids: synthesis and structure analysis.
For a complete list of publications, see
lirias database or
PubMed.
links