Prof. Dr. Peter Verwilst

contact

• see whoiswho
• lab website

research projects

• Exploring CCR5 signaling modulators through integrated computational and synthetic methods [more...]
• Exploring the development of PurK inhibitors in pursuit of novel antibacterial strategies [more...]
• Exploring the under-exploited bacterial purine biosynthesis pathway towards developing novel antibiotics and biochemical tools. [more...]
• An exploration of pincer-type intracellular CCR5 antagonists [more...]
• Development of allosteric intracellular CCR5 signaling modulators to overcome DMPK limitations [more...]
• Harnessing the Power of DNA-Encoded Libraries to Identify and Expand Novel Hits to Develop Urgently Needed P. aeruginosa Antibiotics [more...]
• Design of targeted degraders of LEDGF/p75 with applications as anticancer agents [more...]
• Development of Small-Molecule Inhibitors of FabV Effective in Gram-negative Bacteria [more...]
• Development of FabV inhibitors to combat drug-resistance in pathogenic Gram-negative bacteria [more...]
• Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signalling [more...]

recent publications

• Bulai, R-G., Van Eynde, W., Heylen, S., Cremonini, M., Van Olmen, F., Wicik, R., Lescrinier, E., Rozenski, J., Voet, A., Masschelein, J., Verwilst, P. with Masschelein, J. (corresp. author), Verwilst, P. (corresp. author) (2025). Investigating the structure-activity-relationship of diaryl ether-based paFabV inhibitors: A path to novel antibacterials. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117782. doi: 10.1016/j.ejmech.2025.117782
• Goffin, E., Torfs, L., Tsingis, F., Svestka, D., Erven, K., Uyttersprot, K., Heens, C., Wilms, S., Rozenski, J., Lescrinier, E., Pannecouque, C., Verwilst, P. with Verwilst, P. (corresp. author) (2025). Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 296, Art.No. ARTN 117818. doi: 10.1016/j.ejmech.2025.117818
• Billen, M., Verwilst, P. (sup.), Webster, S. (sup.), Schols, D. (cosup.) (2025). Design, synthesis and biological evaluation of novel intracellular modulators attenuating CCR5 signaling.
• Goffin, E., Verwilst, P. (sup.) (2025). Development and SAR exploration of novel doravirine- and catechol-derived hybrid NNRTIs.
• Billen, M., Reynders, S., Claes, S., Kleinboelting, S., Rozenski, J., Bulai, R-G., Rocca, E., Homer, N.Z M., Webster, S.P., Kaminski, T.P., Lescrinier, E., Schols, D., Verwilst, P. with Verwilst, P. (corresp. author) (2025). Discovery and exploration of disubstituted [1,2,5]oxadiazolo-[3,4-b]pyrazines as novel C-C chemokine receptor type 5 signaling inhibitors targeting the intracellular allosteric binding pocket. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 291, Art.No. ARTN 117600. doi: 10.1016/j.ejmech.2025.117600
• Rocha-Pereira, J., Van Dycke, J., Dos Santos Ferreira, N., Korompai, A., Roux, E., Wevers, N., Goor, S., Molineaux, L., Hubart, A., Dallmeier, K., Hanne, M., Simon, C., Trappeniers, K., Delang, L., Van Dun, C., Lyoo, E., Şen, F., Van Langendonck, M., Meert, R., Minner, K., Verwimp, S., Marques, P.E., Slowikowski, E., Truyen, A., Busselot, W., Mattos, M., Schuermans, S., Sadler, R., Nielsen, V., Degryse, J., Lescrinier, E., Bernardes Pinheiro, V., Verwilst, P., Froeyen, M., Baudemprez, L., Reynders, S., Daelemans, D., Jacquemyn, M., Kwanten, B., Deconinck, T., Aerts, Y., Permentier, B., Van Hauwenhuyse, J., Timmermans, J., Lannoo, R., Libaers, E., Janssens, K., Bral, L., Vanstreels, E., Baggen, J., Dierckx, T., Smolders, Y., Punjwani, J. (2025). Everyone must take action against transmissible diseases - 600 years KU Leuven.
• Goffin, E., Torfs, L., Švestka, D., Erven, K., Uyttersprot, K., Heens, C., Wilms, S., Rozenski, J., Lescrinier, E., Pannecouque, C., Verwilst, P. with Verwilst, P. (corresp. author) (2025). Discovery and SAR Exploration of Novel Nanomolar 3,4-dihydroquinazolin-2(1H)-one Non-Nucleoside Reverse Transcriptase Inhibitors. ChemRxiv. doi: 10.26434/chemrxiv-2025-8l8jw
• Billen, M., Reynders, S., Claes, S., Kleinboelting, S., Rozenski, J., Bulai, R., Rocca, E., Homer, N.Z M., Webster, S.P., Kaminski, T.P., Lescrinier, E., Schols, D., Verwilst, P. (2024). Discovery and Exploration of Disubstituted [1,2,5]Oxadiazolo-[3,4-B]Pyrazines as Novel C-C Chemokine Receptor Type 5 Signaling Inhibitors Targeting the Intracellular Allosteric Binding Pocket. SSRN.
• Kumar, A., George, J.M., Sharma, S., Koyyadi, S., Sharma, S.K., Verwilst, P., Bhatia, A., Patro, S.K., Aggarwal, A., Gupta, S., Sharma, S., Sharma, A. with Kumar, A. (joint first author), George, J.M. (joint first author), Sharma, S. (corresp. author), Sharma, A. (corresp. author) (2024). pH-Activatable Molecular Probe for COX-2 Imaging in Human Oral Squamous Carcinoma Cells and Patient-Derived Tissues. ACS Applied Bio Materials, 7 (12), 8517-8527. doi: 10.1021/acsabm.4c01323
• Vantieghem, T., Aslam, N.A., Osipov, E.M., Akele, M., Van Belle, S., Beelen, S., Drexler, M., Paulovcakova, T., Lux, V., Fearon, D., Douangamath, A., von Delft, F., Christ, F., Veverka, V., Verwilst, P., Van Aerschot, A., Debyser, Z., Strelkov, S.V. with Strelkov, S.V. (corresp. author) (2024). Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 280, Art.No. ARTN 116960. doi: 10.1016/j.ejmech.2024.116960

For a complete list of publications, see lirias database or PubMed.